Tinospora cordifolia in the treatment of chronic and aggressive periodontitis patients with and without dental fluorosis: A clinical, microbiological, and biochemical study
Saubhik Ghosh1, Kharidhi Laxman Vandana1, J Thimmasetty2, Narayan Miskin3, Kishore G Bhat4, Nitya Sharma5
1 Department of Periodontics, College of Dental Sciences, Davangere, Karnataka, India
2 Department of Pharmaceutics, Bapuji Pharmacy College, Davangere, Karnataka, India
3 Department of Pharmacognosy, Bapuji Pharmacy College, Davangere, Karnataka, India
4 Department of Microbiology, Maratha Mandal's N. G. H. Institute of Dental Sciences and Research Centre, Belgaum, Karnataka, India
5 Department of Public Health Dentistry, M. R. Ambedkar Dental College, Bengaluru, Karnataka, India
Kharidhi Laxman Vandana
Department of Periodontics, College of Dental Sciences, Davangere - 577 004, Karnataka
Source of Support: None, Conflict of Interest: None
Purpose: Although inconsistent data prevail in literature, there may be an association of periodontitis with fluorosis (FL). Oxidative stress also contributes to the pathogenesis of periodontitis and is said to be higher in patients with dental FL. Evaluation of the effect of herbal product like guduchi with antimicrobial, antioxidant, and anti-inflammatory properties in the treatment of periodontitis patients with and without dental FL was the main aim of our study.
Materials and Methods: The study was a double-blind, split-mouth study with the control sites being treated with scaling and root planing (SRP) only and the test sites being treated with SRP + guduchi gel (SRP + G). Forty-eight patients who were diagnosed suffering from periodontitis with or without dental FL were divided into four groups and were subject to treatment. Clinical, microbiological, and biochemical parameters were recorded at 0–3 months after treatment.
Results: The clinical and microbiological parameters showed significant difference (P < 0.05) at 3 weeks and 3 months within the SRP + G and SRP treated sites in all the groups. The sites treated with SRP + G in all the groups showed clinically significant improvement than sites treated with SRP alone. However, the control and test sites of fluorosed and nonfluorosed periodontitic patients showed similar improvements in clinical, microbiological, and biochemical parameters.
Conclusion: Guduchi gel (6.25%) has clinically significant anti-inflammatory and antimicrobial effects along with SRP. Increasing the concentration of the gel on a larger sample size would render it more effective in the nonsurgical therapy of periodontitis.