International Journal of Oral Health Sciences

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 6  |  Issue : 1  |  Page : 11--17

Periodontal regeneration by application of recombinant human bone morphogenetic protein-2 in human periodontal intraosseous defects: A randomized controlled trial


Kharidi Laxman Vandana1, Ganesh Singh1, Shobha Prakash1, Kala S Bhushan1, Neha Mahajan2 
1 Department of Periodontics, College of Dental Sciences, Davangere, Karnataka, India
2 Department of Periodontics, Himachal Dental College, Sundernagar, Himachal Pradesh, India

Correspondence Address:
Kharidi Laxman Vandana
Department of Periodontics, College of Dental Sciences, Davangere, Karnataka
India

Background: Recombinant human bone morphogenetic protein-2 (rhBMP-2) technologies have been shown to significantly support alveolar bone. The purpose of this study was to explore the effect of rhBMP-2 following periodontal flap surgery in vertical defects on clinical and radiological parameters. Methods: A randomized double-blind controlled trial was carried out, wherein rhBMP-2 was used in the test group after open flap debridement (OFD). The control group was only OFD. The same examiner carried out both clinical and radiographic measurements at baseline, 6 and 9 months. Results: In rhBMP-2 + OFD sites, the probing pocket depth reduction was 1.45 ± 0.76, 2.50 ± 0.69 at 6 months and 9 months, respectively (both P < 0.001) and clinical attachment gain was 0.92 ± 0.76, 1.31 ± 0.48 at 6 months, and 9 months, respectively (both P < 0.001). Radiographic fill was 1.14 ± 0.73, 1.85 ± 0.83 at 6 months, and 9 months postoperatively (P < 0.001) and percentage of original defect resolved at 6 and 9 months was 40.2 ± 18.6, 60.1 ± 15.8, respectively. Conclusions: The periodontal therapy can include rhBMP-2 to enhance periodontal regeneration. The clinical and radiographic improvement are demonstrated in this study.


How to cite this article:
Vandana KL, Singh G, Prakash S, Bhushan KS, Mahajan N. Periodontal regeneration by application of recombinant human bone morphogenetic protein-2 in human periodontal intraosseous defects: A randomized controlled trial.Int J Oral Health Sci 2016;6:11-17


How to cite this URL:
Vandana KL, Singh G, Prakash S, Bhushan KS, Mahajan N. Periodontal regeneration by application of recombinant human bone morphogenetic protein-2 in human periodontal intraosseous defects: A randomized controlled trial. Int J Oral Health Sci [serial online] 2016 [cited 2019 Oct 21 ];6:11-17
Available from: http://www.ijohsjournal.org/article.asp?issn=2231-6027;year=2016;volume=6;issue=1;spage=11;epage=17;aulast=Vandana;type=0