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REVIEW ARTICLE
Year : 2020  |  Volume : 10  |  Issue : 1  |  Page : 19-25

Paget's disease of bone with special reference to dentistry: An insight


1 Department of Oral Pathology, Rayat Bahra Dental College and Hospital, Mohali, Punjab, India
2 Department of Oral Pathology, Laxmibai Institute of Dental Sciences and Hospital, Patiala, Punjab, India

Correspondence Address:
Dr. Sonia Gupta
#95/3, Adarsh Nagar, Dera Bassi, Mohali - 140 507, Punjab
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijohs.ijohs_53_14

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Paget's disease of bone (PDB) is a relatively common disorder of uncertain etiology. It is characterized by abnormal resorption and apposition of osseous tissue in one or more bones of the skeleton. Although many patients are asymptomatic, a variety of symptoms and complications may occur. Jaw involvement is seen in approximately 17% of cases, and usually, it is the maxilla that is involved. PDB begins with a period of increased osteoclastic activity and bone resorption, followed by increased osteoblast production of woven bone that is poorly mineralized. In the final phase of the disease process, dense cortical and trabecular bone deposition predominates, but the bone is sclerotic and poorly organized and lacks the structural integrity and strength of normal bone. This article discusses the prevalence, etiology, clinical features, radiography, histopathology, biochemistry, oral and dental manifestations, complications, and the treatment of PDB.


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